中文名 | 洛伐他汀钠 |
英文名 | Lovastatin Hydroxy Acid, Sodium Salt |
别名 | 洛伐他汀钠 洛伐他丁羟酸钠 洛伐他汀羟基酸钠 洛伐他汀EP杂质B 洛伐他汀羟酸盐(酸式莫奈可林) 洛伐他汀羟酸钠盐溶液, 100PPM 1,2,6,7,8,8a-六氢-2,6-二甲基-8-(2-甲基丁酰氧基)-1-萘-3',5'-二羟基庚酸钠盐 |
英文别名 | MB 530B LOVASTATIN SODIUM sodium mevinolinate LOVASTATIN SODIUM SALT Lovastatin Hydroxy Acid Lovastatin EP IMpurity B LOVASTATIN HYDROXY ACID, SODIUM SALT Lovastatin Hydroxy Acid, Sodium Salt sodium (3R,5R)-7-[(1S,2S,6R,8S,8aR)-2,6-dimethyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate [1s-[1a(bs,ds),2a,6b,8b(r),8aa]]-1,2,6,7,8,8a-hexahydro-b,d-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic acid monosodium salt |
CAS | 75225-50-2 |
化学式 | C24H37NaO6 |
分子量 | 444.54 |
InChI | InChI=1/C24H38O6.Na/c1-5-15(3)24(29)30-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-18(25)12-19(26)13-22(27)28;/h6-7,10,14-16,18-21,23,25-26H,5,8-9,11-13H2,1-4H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,18+,19+,20-,21-,23-;/m0./s1 |
熔点 | 154-160°C |
沸点 | 602.3°C at 760 mmHg |
闪点 | 199.1°C |
蒸汽压 | 5.09E-17mmHg at 25°C |
溶解度 | 溶于DMSO |
存储条件 | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
稳定性 | 吸湿性 |
外观 | 白色固体。 |
体外研究 | Mevinolin in the hydroxy-acid form, mevinolinic acid, is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase [mevalonate: NADP + oxidoreductase (CoA-acylating)]. |
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